Another less common use of the extra-diegetic gaze is to isolate a single character from the other characters in a scene. By making the character look outside of the frame, they appear isolated from the people and things within it.
Lazzam, David. "What Are You Looking At? The Extra-Diegetic Gaze in Marjane Satrapi's Persepolis." Comics in Education, 28 Feb. 2015. Web.